Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men
نویسندگان
چکیده
منابع مشابه
Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men.
The loss of skeletal muscle mass during aging, sarcopenia, increases the risk for falls and dependence. Resistance exercise (RE) is an effective rehabilitation technique that can improve muscle mass and strength; however, older individuals are resistant to the stimulation of muscle protein synthesis (MPS) with traditional high-intensity RE. Recently, a novel rehabilitation exercise method, low-...
متن کاملActivation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin.
Restriction of blood flow to a contracting muscle during low-intensity resistance exercise (BFR exercise) stimulates mTORC1 signaling and protein synthesis in human muscle within 3 h postexercise. However, there is a lack of mechanistic data to provide a direct link between mTORC1 activation and protein synthesis in human skeletal muscle following BFR exercise. Therefore, the primary purpose of...
متن کاملBlood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis.
Low-intensity resistance exercise training combined with blood flow restriction (REFR) increases muscle size and strength as much as conventional resistance exercise with high loads. However, the cellular mechanism(s) underlying the hypertrophy and strength gains induced by REFR are unknown. We have recently shown that both the mammalian target of rapamycin (mTOR) signaling pathway and muscle p...
متن کاملReactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise.
Blood flow restriction (BFR) to contracting skeletal muscle during low-intensity resistance exercise training increases muscle strength and size in humans. However, the mechanism(s) underlying these effects are largely unknown. We have previously shown that mammalian target of rapamycin complex 1 (mTORC1) signaling and muscle protein synthesis (MPS) are stimulated following an acute bout of BFR...
متن کاملActivation of mTORC1 Signaling and Protein Synthesis in Human Muscle
41 Restriction of blood flow to a contracting muscle during low-intensity resistance 42 exercise (BFR exercise) stimulates mTORC1 signaling and protein synthesis in human 43 muscle within 3 hours post-exercise. However, there is a lack of mechanistic data to 44 provide a direct link between mTORC1 activation and protein synthesis in human 45 skeletal muscle following BFR exercise. Therefore, th...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2010
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.01266.2009